MidwestWeekends.com — Your Travel Guide to the Upper Midwest

Road trip from southern Illinois to western Iowa

My husband is handicapped, so our vacation has to be mainly a road trip. We would at some point like to go to Cherokee, Iowa. Driving is not a problem, as we drove to Alaska and back. Can you tell me about scenic routes to take? We are from the farm so prefer rural areas over large cities. - Betty, Liberty, Ill.

I'd suggest following the Lewis & Clark Trail along the Missouri River from St. Louis. There are lots of guidebooks that will tell you about the many historical and natural sights along the river. 

If you want, you can start at the Gateway Arch and Museum of Westward Expansion in St. Louis, or go straight to the interesting little towns along the river St. Charles, Hermann in wine country, Boonville and so on.

You can see lots of Civil War and presidential sites in western Missouri, in Independence, Lexington and Weston, and then you'll head north to St. Joseph, the start of the Pony Express.

In southwest Iowa, you can either continue along the river on the Lewis & Clark Trail to Sioux City or drive north on the Loess Hills Scenic Byway.

At the end of the byway, in Akron, it's just an hour's drive east on Iowa 3 to Cherokee.

Last updated on May 9, 2012